Kleine-Levin Syndrome

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

Also Known As:

Syndrome, Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome; Familial Kleine Levin Syndrome; Hibernation Syndrome, Kleine-Levin; Kleine Levin Critchley Syndrome; Kleine Levin Hibernation Syndrome; Kleine Levin Syndrome; Kleine-Levin Syndrome, Familial; Periodic Hypersomnia; Periodic Hypersomnias; Syndrome, Familial Kleine-Levin; Syndrome, Kleine-Levin Hibernation; Syndrome, Kleine-Levin-Critchley; Hypersomnia, Periodic

Nervous System Diseases: 14737
- Sleep Wake Disorders: 3817
  - Dyssomnias: 27
    - Intrinsic Sleep Disorders: 11
      - Disorders of Excessive Somnolence: 2522
        Kleine-Levin Syndrome: 90
Mental Disorders: 25040
- Sleep Wake Disorders: 3817
  - Dyssomnias: 27
    - Intrinsic Sleep Disorders: 11
      - Disorders of Excessive Somnolence: 2522
        Kleine-Levin Syndrome: 90

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Drug/Important Bio-Agent (IBA)